Multiple cell and population-level interactions with mouse embryonic stem cell heterogeneity

Multiple cell and population-level interactions with mouse embryonic stem cell heterogeneity.

Much of development and disease concerns the generation of gene expression differences between related cells sharing similar niches. However, most analyses of gene expression only assess population and time-averaged levels of steady-state transcription. The mechanisms driving differentiation are buried within snapshots of the average cell, lacking dynamic information and the diverse regulatory ...

Differentiation of Mouse Embryonic Stem Cell into Insulin-Secreting Cell

Purpose: Differentiation of mouse embryonic stem cells into Insulin secreting endocrine cells. Materials and Methods: In this study, Royan B1 mouse embryonic stem cell (derived from C57BL/6 mouse) were used. In directed differentiation method, embryonicstem cells after embryoid bodies formation were differentiated into insulin secreting cells. Nestin positive cells were obtained after culture ...

P-92: Retinoic Acid and STO Co-Culture System Enhance Mouse Embryonic Stem Cell

The effect of BMP4 on mouse embryonic stem cell proliferation and differentiation into primordial germ cells

Background and Aim: Artificial gamete production from stem cells is a novel strategy for treatment of infertility. Among various stem cell sources, embryonic stem cells (ESC) can be considered as an appropriate source for in vitro formation of germ cells. In this study we evaluated the effect of BMP4 on proliferation and differentiation of mouse embryonic stem cells into primordial germ cells (...

Cell‐cell and Cell‐medium Interactions in the Growth of Mouse Embryonic Stem Cells

....................................................................................................................................................... 6 Chapter 1: Introduction ................................................................................................................................ 8 1.1 Growth of cells in culture ............................................................